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Chinese pharma company is starting trials of an inhaled COVID-19 vaccine
Published on: 2021-04-20
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China’s CanSino Biologics will be starting clinical trials for a Covid-19 vaccine that is administered through inhalation next week, the company’s co-founder and Chief Executive Xuefeng Yu said on Sunday.
 

Efficacy rates for China’s Covid vaccines have been found to be lower than those developed by Pfizer-BioNTech and Moderna. Earlier this month, the director of the Chinese Center for Disease Control publicly acknowledged that Chinese vaccines “don’t have very high protection rates” and that they were considering giving people different Covid shots to boost vaccine efficacy.
 

An inhaled vaccine could be more effective than those injected given that the coronavirus enters the human body through the airways.
 

CanSinoBIO is jointly developing the inhalation vaccine with the Beijing Institute of Biotechnology. To be clear, the company’s Adenovirus Type 5 Vector vaccine — or Ad5-nCoV — administered by injection was already approved for use in China and several other countries.
 

Theoretically, an inhaled vaccine could provide additional protection by activating antibodies or T cells — white blood cells that are vital to the immune system — in the airways.
 

If that protection layer fails and the virus travels deeper into the body, other parts of the immune system could still fight the Covid virus.
 

康希诺生物董事长:吸入式新冠疫苗临床试验年内肯定会有结果

“我们先把临床试验做完,年内肯定会有结果,我也很有信心,(吸入式疫苗)是个很好的途径”。4月19日,在博鳌亚洲论坛2021年年会期间,康希诺生物联合创始人、董事长兼首席执行官宇学峰透露了吸入式新冠疫苗的最新研究进展。
 

3月23日,康希诺生物宣布,与军事科学院军事医学研究院生物工程研究所合作开发的吸入用重组新型冠状病毒疫苗(5型腺病毒载体)已获得国家药品监督管理局药物临床试验批件。
 

吸入用重组新冠疫苗与2月25日获得附条件批准上市的重组新冠疫苗(5型腺病毒载体)的毒种、细胞库、原液生产工艺、制剂生产工艺、制剂配方等均相同,仅在使用时采用雾化吸入免疫专用装置进行免疫。
 

宇学峰介绍,根据现在的一些研究,表明吸入式新冠疫苗只要用 1/ 5 的剂量就能达到和打一针同样的效果。产能上,康希诺生物天津工厂2亿至3亿剂,已经上线,逐渐月月有产出。另外,康希诺生物与上海医药合作的工厂也在紧锣密鼓建设中,未来两三个月将投产,产能也在2亿至3亿剂,即未来有5亿剂的年产能,“用吸入给药的话,可以节约很多,保守估计在20%的用量”。
 

2月25日,康希诺生物与军事科学院合作研发的重组新型冠状病毒疫苗(5型腺病毒载体)克威莎TM获得国家药品监督管理局批准附条件上市,成为国内首个获批的腺病毒载体新冠疫苗,也是中国目前获批上市唯一采用单针免疫程序的新冠疫苗。

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