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Three-shot recombinant COVID-19 vaccine now available in Beijing, coming soon in Tianjin
Published on: 2021-05-31
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A three-shot recombinant protein COVID-19 vaccine developed in China is now available in Beijing.
 

The vaccine (CHO Cells) was jointly developed by the Institute of Microbiology under the Chinese Academy of Sciences and Anhui Zhifei Longcom Biopharmaceutical Co. Ltd. Researchers from the institute have been receiving their first jabs in Beijing's Haidian District since Thursday.
 

China authorized the emergency use of the vaccine on March 10, and people from many provinces including Anhui and Hubei have since received the vaccine. On May 3, the first batch of the vaccine was rolled off the production line in Beijing, according to the institute.
 

The results of phase two trials, which involved people aged between 18 and 59, show that 83 percent of participants produced neutralizing antibodies after two doses of the vaccine, and 97 percent produced neutralizing antibodies after three doses.
 

The early-stage trials, conducted among people aged 60 and above, show that the seroconversion rate of neutralizing antibodies reached 95 percent after three doses, with no serious adverse reactions related to vaccination.
 

The recommended interval between vaccine doses is one month.
 

北京开始接种“三针”疫苗

“三针”疫苗即基因重组亚单位疫苗,这一类疫苗和之前已经获批的灭活疫苗以及腺病毒载体疫苗都不同,完成免疫接种程序,需要打3针,间隔1个月时间。
 

据介绍,这款“三针”疫苗由中国科学院微生物研究所与安徽智飞龙科马生物制药有限公司联合研制。该疫苗为重组亚单位疫苗,采用DNA重组技术,由重组CHO细胞表达的新型冠状病毒刺突糖蛋白受体结合区NCP-RBD蛋白,经过纯化加入氢氧化铝佐剂制成混悬型注射液。该疫苗于3月17日获批紧急使用。接种后,可刺激机体产生抗新型冠状病毒的免疫力。
 

目前,我国有一共五款新冠疫苗,分三大类:灭活疫苗、重组亚单位疫苗和腺病毒载体疫苗。中科院专家表示,“重组亚单位疫苗免疫接种对人很安全,前期的临床数据显示,接种重组蛋白苗后,抗体水平较高。”
 

同时,新冠重组蛋白苗不需要高等级生物安全实验室生产车间,可以快速实现大规模产业化生产,显著降低了疫苗生产成本,且存储和运输便捷。这款疫苗的接种程序和我们熟知的乙肝疫苗类似,需要接种三针,目前主要用于18岁以上人群。
 

海淀区疾病预防控制中心计划免疫科科长史如晶说,“三针”重组蛋白疫苗接种点暂时设立在北京小荷门诊部,海淀区居民在网上预约即可接种。

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