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A COVID-19 nasal spray vaccine applies for emergency use in China
Published on: 2021-06-04
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A COVID-19 nasal spray vaccine has applied for emergency use to China's National Medical Products Administration, the prominent Chinese vaccine developer, Chen Wei, revealed on Thursday.
 

The nasal spray vaccine, jointly developed by Chen's team and the Chinese biotech company, CanSino Biologics Inc, only requires one-fifth of the amount of the injectable adenovirus vector COVID-19 vaccine and doesn't need cold-chain storage and transport, Chen introduced in a speech delivered at the Pujiang Innovation Forum in Shanghai on Thursday.
 

The current injectable COVID-19 vaccine is 0.5 milliliter per dose, said Shanghai-based vaccine expert, Tao Lina. If Chen's nasal spray vaccine can achieve the same protective effect with only a 0.1 milliliter dose, "that means it has higher immune efficiency," Tao said.
 

The higher efficiency may come from the way the vaccine enters body, Tao said. It is directly inhaled through the nose, which mimics the natural infection of the respiratory virus COVID-19, and then it forms a mucosal immunity, he explained.
 

雾化吸入式新冠疫苗正在申请紧急使用

在6月3日下午举行的2021浦江创新论坛全体大会上,军事科学院研究员、中国科协副主席、中国工程院院士陈薇透露,团队研制的雾化吸入式新冠疫苗已获药监局批准进行扩大临床试验,现在正在申请紧急使用。
 

“现在都是‘打疫苗’,疫苗其实还可以通过别的方式接种的。”陈薇说,团队一直在探索“双非疫苗”的研发,即非注射、非冷链,比如雾化吸入的方式。
 

陈薇解释说,雾化吸入式疫苗只需针剂疫苗的五分之一的剂量,且不用一瓶一瓶装,疫苗瓶子的瓶颈问题也可以解决。此外,相较于注射式新冠疫苗形成的体液免疫、细胞免疫,吸入式新冠疫苗还可形成黏膜免疫,这三重免疫是最理想的状态。
 

资料显示,所谓雾化吸入免疫,即采用雾化器将疫苗雾化成微小颗粒,通过呼吸吸入的方式进入呼吸道和肺部,从而激发黏膜免疫,而这种免疫是通过肌肉注射所不能带来的。此外,使用雾化吸入方式免疫是无痛的,且拥有更高的可及性。

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