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HIV-positive woman carries coronavirus for 216 days, develops 32 mutations
Published on: 2021-06-09
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An HIV-positive 36-year-old woman in South Africa, who had contracted COVID-19, carried the virus for as many as 216 days. Further, the SARS-CoV-2 virus mutated 32 times inside the woman's body during this period.
 

As per the study, 13 mutations happened in the coronavirus's spike protein which helps the virus beat the human body's immune response, while the remaining 19 mutations were linked to the behaviour of the contagion.
 

It was immediately not clear whether the woman passed on the virus to anyone else.
 

Scientists are suspecting that if this behaviour of the virus is established in other patients as well, then it could be possible that HIV infection is creating more variants of the SARS-CoV-2 virus.
 

The study also suggests that immunosuppressed people are likely to host the coronavirus longer than usual.
 

216天32次变异!当新冠病毒“撞上”艾滋病毒

南非研究人员在一位患有晚期HIV的36岁南非女性体内发现了潜在危险的新冠病毒突变。据悉,这名女性携带新冠病毒长达216天,在此期间,新冠病毒在她的体内发生了32次突变,其中包括13次关键的刺突蛋白突变。这一新发现引发了人们的担忧,即艾滋病毒和新冠病毒的“碰撞”可能会使根除新冠大流行的努力复杂化。
 

据报道,这项研究发现于6月3日作为预印本发表在medRxiv平台上。这份报告显示,该女子在2006年被确诊患有艾滋病。随着时间的推移,她的免疫系统一直在变弱。在2020年9月感染新冠后,她体内检测到的新冠病毒在关键突刺蛋白上出现了13次突变,以及其他19次可能改变病毒行为的基因变化,这其中包括了英国变种E484K及南非变种N510Y。
 

该研究作者、南非纳塔尔大学遗传学家图略•德•奥利维拉表示,这个病例很容易被忽视,因为这名女性最初在医院接受治疗后,尽管仍持续携带新冠病毒,但她只表现出了轻微的新冠肺炎症状。研究人员之所以能发现这个病例,是因为她参与了一项针对300名艾滋病毒感染者对新冠病毒免疫反应的研究。
 

目前,尚不清楚该女子所携带的变异病毒是否已传染给他人。研究人员还指出,南非纳塔尔省新变种的频繁出现和该地区艾滋病的高流行之间可能存在联系。据悉,该地区超过四分之一的成年人是HIV阳性。

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